Zymes llc. Achieving Solubility

Achieving Solubility

Zymes LLC has exclusive worldwide rights to the Ubisol-Aqua™ solubilization technology developed at the National Research Council (NRC) of Canada. Ubisol-Aqua™ is a patented family of neutral, non-ionic carriers for water-insoluble compounds. The family includes our proprietary compounds PTS™, PCS™, and PSS™.

The water insoluble substance to be solubilized forms a non-covalently bound complex with Ubisol-Aqua™, which has both hydrophobic and hydrophilic subsections. This leads to self-assembly into micellar arrays with a hydrophobic interior and a hydrophilic exterior shell when mixed with water. For example, when PTS™ solubilizes coenzyme Q₁₀, nano-micelles that measure 22±7 nm in diameter form in solution. A transmission electron micrograph of a single micelle is shown in the following image.

Transmission electron micrograph of Ubisol-Aqua™: Coenzyme Q₁₀ micelle

The solubilized complex is both water and lipid soluble and stable through a wide range of temperatures (-80 to 120 °C), phase changes (freezing, melting) and across a broad pH range (2.0-8.0).

The Ubisol-Aqua™ technology has successfully solubilized a number of bioactive molecules including: coenzyme Q₁₀, idebenone, vitamin A acetate, vitamin A palmitate, vitamin B pentapalmitate, squalene, α-tocopheryl acetate, fish oil (EPA/DHA), β-carotene, astaxanthin, squalene, asiatic acid, essential oils and polyene macrolide antibiotics (amphotericin B, nystatin and erythromycin).

The figure below illustrates a micelle formed by mixing PTS™ with coenzyme Q₁₀ in water. Click on the figure to view an animation demonstrating how to achieve solubility with Ubisol-Aqua™.

Achieving solubility with Ubisol-Aqua™

Functionality

• Science and Technology
  • Overview
  • Zymes’ Coenzyme Q₁₀
    • HQO™
  • Omega-3
  • Ubisol-Aqua™ Delivery System Technology
    • Achieving Solubility
    • Functionality
    • Applications
  • Green Chemistry
  • Published Research
  • Ongoing Research